Iptables rules for nat to apache ip based virtual hosts

Hello together, I have got one official ip address and a dmz with an apache webserver with ip based virtual hosts config. Now I have got the problem, that my prerouting / forward rule does not work properly. E.g. iptables -t nat -A PREROUTING -i $INF -p tcp --sport 1024: -d www.mydomain.com --dport 80 -j DNAT --to 1.2.3.4:80 iptables -A FORWARD -p tcp -d 1.2.3.4 --dport 80 -i $INF -j ACCEPT This does work for one domain. But of course any further prerouting rule is set to the first nat ip address. Do I need an application level gateway for this config or could this feature be achieved by iptables? Thanks for any advice! Regards, Stefan