sysctl variables changes becoming active on upadting packages?

Hi, we are wondering if sysctl values in on of the /etc/sysctl* directories change via a packageupdate, if they should become active immediately, or only ever on next reboot. e.g. running /usr/lib/systemd/systemd-sysctl in %post of such packages would make them active, but could overwrite admin set values. Ciao, Marcus