minicom - how to "reset" a serial line?

I'm using minicom for talking to a storage array over a serial line connected via null-modem. Every now and then the "conversation" gets screwed up, typically when I close minicom - on the next session, I only get gobbledegook from the array. I've tried sending breaks - so far nothing's worked. Does anyone have a tip on how to "reset" the serial line from minicom? /Per Jessen, Zürich