Also for the last 2 weeks OBS will not run without ipv6.

I had to enable it to get OBS to work my project.

It was disabled in the kernel and I had to enable it to make obs work

Kept getting no path to api.opensuse.org but I could ping the ipv4 address.

nslookup api.opensuse.org
Server:        1.1.1.2
Address:    1.1.1.2#53

Non-authoritative answer:
api.opensuse.org    canonical name = obs-login.opensuse.org.
Name:    obs-login.opensuse.org
Address: 195.135.221.162
Name:    obs-login.opensuse.org
Address: 2001:67c:2178:8::162

So something in the latest updates requires ipv6 to work.

I started with a fresh Tumbleweed system on a x86_64 system.

Installed clamav, amavis-new and spamassassin. I adapted the .conf files a bit 
and have in amavisd.conf :

#@mynetworks = qw( 127.0.0.0/8 [::1] [FE80::]/10 [FEC0::]/10
#                  10.0.0.0/8 172.16.0.0/12 192.168.0.0/16 );
@mynetworks = qw( 127.0.0.0/8 );

This seems the solution to the error message when starting amavis.service

nov 23 17:46:08 eiktum amavis[1242]: perl=5.036000, user=, EUID: 65 (65);  
group=, EGID: 65 65 (65 65)
nov 23 17:46:09 eiktum amavis[1242]: (!)Net::Server: 2022/11/23-17:46:09 Can't 
connect to TCP port 10024 on ::1 [Cannot assign requested address]\n  at line 
64 in file /usr/lib/perl5/vendor_perl/5.36.0/Net/Server/Proto/TCP.pm
nov 23 17:46:09 eiktum systemd[1]: amavis.service: Main process exited, 
code=exited, status=1/FAILURE
nov 23 17:46:09 eiktum systemd[1]: amavis.service: Failed with result 'exit-
code'.
nov 23 17:46:09 eiktum systemd[1]: Failed to start Amavisd-new Virus Scanner 
interface.

I don't have a IPv6 network, so I disabled this in the network configuration.

Any suggestions?