openSuSE Leap 15.4 x86_64, kernel 4.14.21-150400.22-default, in a Lenovo
IdeaPad 3 15ADA05:
https://psref.lenovo.com/syspool/Sys/PDF/IdeaPad/IdeaPad_3_15ADA05/IdeaPad_3_15ADA05_Spec.PDF

An external mouse stops working after a brief period of time, after login into
KDE, or after removing and loading xhci_pci & xhci_hcd.

System complaints of:
���xhci_hcd 0000:02:00.3 WARNIGN: Host System Error���
and:
���usb 2-3: device not accepting address 2, error -108���

I've tried two bluetooth mice, and a standard cord mouse. The same result.

It seems that it's the USB controllers are the only components affected, so
far. Mousepad works properly, but I'm not use to it.

I have to constantly remove and load xhci_pci & xhci_hcd, as root.

rmmod xhci_pci
rmmod xhci_hcd
modprobe xhci_pci
modprobe xhci_hcd

Mouse works after that for a short time.

Nota bene: Devices work properly under openSuSE Leap 15.2 x86_64, kernel
5.3.18-lp152.106-default (old HP Pavillion).

This bug resembles https://bugzilla.opensuse.org/show_bug.cgi?id=1193652