Hard to know. btrfs can only detect those issues via checksuming but is itself not able to tell you where they come from - they can originate from basically anywhere. Faulty hardware or bad connectors are by far more likely than a filesystem issue itself. IMHO - don't bother trying to repair such issues. If you could save the data elsewhere then nuke the filesystem and start over. I would be suspicious on the hardware itself and wouldn't rely on it for a couple of months after such a failure, i.e. always keep backups and assume it's going to shoot itself in the foot again. At this point I would say it's safe to assume the disk is somehow flanky until proven otherwise. But those are just my two cents - Your hardware, your rules :-)