Manually doing the following make it working ln -s /usr/lib64/apache2/mod_wsgi_python3.so /usr/lib64/apache2-event/mod_wsgi_python3.so + Modifying the /etc/apache2/sysconfig.d/loadmodule.conf LoadModule wsgi_module /usr/lib64/apache2-event/mod_wsgi_python3.so Make it useable. But I'm pretty sure everything would explode if python2 and python3 are loaded together.