Frankly, I am not understanding your setup either. Cross guest communication is not the purpose, and network-manager is not the topic (either on the host or the guest). Your test may not work for a variety of reasons, including firewalling, and it is too complicated for the purpose of this report. Here would be a quick test : 1. Fire up a simple guest with a vboxnet0 interface and start a listener (after obtaining a DCHP address with dhclient or network-manager) : netcat -l -p9999 -v 2. From the host, try : netcat <guest IP> 9999 -v If the hosts gets an IP address in vboxnet0 and can reach the guest over the 192.168.56.0/24 network, then problem solved. Otherwise, still an issue.