This appears to be due to the new nodejs-libpath.patch - specifically this chunk: Index: node-v5.6.0/lib/module.js =================================================================== --- node-v5.6.0.orig/lib/module.js +++ node-v5.6.0/lib/module.js @@ -459,7 +459,13 @@ Module._initPaths = function() { homeDir = process.env.HOME; } - var paths = [path.resolve(process.execPath, '..', '..', 'lib', 'node')]; + if fs.exists('/usr/lib64', fs.F_OK, function(err) { + if (!err) { + var paths = ['/usr/lib/node','/usr/lib64/node']; + } else { + var paths = ['/usr/lib/node']; + } + }; if (homeDir) { paths.unshift(path.resolve(homeDir, '.node_libraries')); fs.exists only takes two arguments; given the three arguments it seems like fs.access was intended, although being an asynchronous function it would still not have the intended effect. I believe that the following code instead has the intended effect: try { fs.accessSync('/usr/lib64', fs.F_OK); var paths = ['/usr/lib/node','/usr/lib64/node']; } catch (e) { var paths = ['/usr/lib/node']; } https://nodejs.org/api/fs.html#fs_fs_accesssync_path_mode When tested on a 64-bit OS, the results are as expected: ~/rpmbuild/BUILD/node-v5.6.0$ out/Release/node > require('module').globalPaths [ '/home/<redacted>/.node_modules', '/home/<redacted>/.node_libraries', '/usr/lib/node', '/usr/lib64/node' ] I will attach the altered nodejs-libpath.patch file for reference.