Created attachment 852303 [details]
boot log of systemd-tmpfiles-setup

the last systemd package version 246.15-7.11.1 provides a
systemd-tmpfiles-setup service which doesn't reliably create all configured
paths.
I had to manually execute the underlying commmand of the
systemd-tempfiles-setup after the boot to get all paths:
/usr/bin/systemd-tmpfiles --create --remove --boot --exclude-prefix=/dev 

Often affected services were mariadb with missing /run/mysql directory
(/usr/lib/tmpfiles.d/mariadb.conf), zabbix_agentd with missing /run/zabbix
directory (configuration under /usr/lib/tmpfiles.d/zabbix_agentd.conf).
It seems that this is a runtime exception because these services were not
always affected.
A new boot after manual correction is working without problems and
systemd-tmpfiles-setup doesn't harm the system again.