(In reply to Stefan Dirsch from comment #1) > Hmm. I wasn't aware of this at all. So > > nvngx.dll --> /lib/nvidia/wine > _nvngx.dll --> /lib64/nvidia/wine > > Is this correct? The DLLs should both be in the same folder, i.e.: nvngx.dll --> /usr/lib/nvidia/wine _nvngx.dll --> /usr/lib/nvidia/wine The ./nvidia/wine folder needs to be relative to the libGLX_nvidia.so file. On my oS install, I see this .so file is provided in both /usr/lib/ and /usr/lib64/. For reference, on Arch-based systems, the nvngx.dll and _nvngx.dll files are located in /usr/lib/nvidia/wine. It might be worth checking where the .run file by NVIDIA places the files too, as I believe they are also available in /usr/lib64/nvidia/wine when the drivers are installed with the run file.