Please remember my first statement: it works until version 25, it fails since version 26. So of course I've installed version 25 currently. To your hints: 1. in UEFI-BIOS I can see both NVMe in the menu where I can select the boot order. So both NVMe should be bootable. 2. I entered grub command line from boot menu with version 25: 2.1 grub> ls shows both NVMe devices as (hd0) and (hd1) and all partitions on both. The rescuezilla.iso is in (hd1,gpt5). So I started with grub> ls (hd1,gpt5) that shows long technical data with fs, mod time, UUID, startpoint and capacity. Then I continued with grub> ls (hd1,gpt5)/boot/iso/rescuezilla.iso with this result: rescuezilla.iso grub> 3. Now I installed grub version 27 and repeated the procedure 3.1 same result as 2.1 with grub> ls and grub> ls (hd1,gpt5) But grub> ls (hd1,gpt5)/boot/iso/rescuezilla.iso now shows an error: error: ../../grub-core/kern/mm.c:372:out of memory That confirms my assumption: since version 26 something has changed and it's not a problem on my notebook. Meanwhile version 25 is active again and everything works fine.