Comment # 13 on bug 1132911 from Takashi Iwai

Also could you test the latest 5.1-final kernel available in OBS Kernel:HEAD
repo?  The upstream got a regression fix
72bfcee11cf89509795c56b0e40a3785ab00bbdd
    i2c: Prevent runtime suspend of adapter when Host Notify is required

and this might be your issue, too.