When working on reproducible builds for openSUSE I found that
some packages use pip install which creates .pyc files
that contain a random tmp path in them that is different for every build

affects at least:
python-cluster
python-jupyter_bqplot
python-jupyter_imatlab_kernel
python-PsyLab
python-sphinxcontrib-github-alt

here is an example diff:

/usr/lib/python3.6/site-packages/cluster/method/__pycache__/kmeans.cpython-36.pyc
@@ -110,7 +110,7 @@
 000006d0  00 5a 0e 63 6f 6e 74 72  6f 6c 5f 6c 65 6e 67 74  |.Z.control_lengt|
 000006e0  68 da 04 69 74 65 6d a9  00 72 13 00 00 00 fa 3a  |h..item..r.....:|
 000006f0  2f 74 6d 70 2f 70 69 70  2d 69 6e 73 74 61 6c 6c  |/tmp/pip-install|
-00000700  2d 32 75 38 6a 6f 79 74  76 2f 63 6c 75 73 74 65  |-2u8joytv/cluste|
+00000700  2d 6e 69 6c 34 6b 39 77  73 2f 63 6c 75 73 74 65  |-nil4k9ws/cluste|
 00000710  72 2f 63 6c 75 73 74 65  72 2f 6d 65 74 68 6f 64  |r/cluster/method|
 00000720  2f 6b 6d 65 61 6e 73 2e  70 79 da 08 5f 5f 69 6e  |/kmeans.py..__in|
 00000730  69 74 5f 5f 2e 00 00 00  73 20 00 00 00 00 01 06  |it__....s ......|

IMHO, those .pyc files should not contain any tmp path
because it does not exist in the target system anyway.