Comment # 30 on bug 1175201 from Larry Finger

(In reply to James Moe from comment #28)
> Did all of that, ignored the warnings. No workee.
> 
> As usual this command was needed:
> sudo chmod 4750 /usr/lib/virtualbox/VirtualBoxVM
> 
> Starting the Vbox manager:
> 2020-08-30T12:03:21-0700 sma-station14l systemd[4445]: Started Application
> launched by gnome-shell.
> 2020-08-30T12:03:21-0700 sma-station14l virtualbox.desktop[20641]:
> /usr/lib/virtualbox/VirtualBox6: symbol lookup error:
> /usr/lib/virtualbox/VirtualBox6: undefined symbol:
> _ZN17QIDialogContainer20setProgressBarHiddenEb
> 
> Starting a guest from a desktop icon:
> 2020-08-30T12:03:36-0700 sma-station14l
> com.github.spheras.desktopfolder.desktop[20655]: VirtualBoxVM:
> supR3HardenedMainGetTrustedMain:
> dlopen("/usr/lib/virtualbox/VirtualBoxVM.so",) failed:
> /usr/lib/virtualbox/VirtualBoxVM.so: undefined symbol:
> _ZN20UIPerformanceMonitor28sltGuestAdditionsStateChangeEv

What permissions level are you running? Check the value for PERMISSION_SECURITY
in /etc/sysconfig/security. For most systems, it has "easy,local". The
permissions package sets 4750 for VirtualBoxVM in
/usr/share/permissions/permissions.easy. The secure and paranoid settings have
0750.

As to your missing symbols, I cannot find either of them in the sources.