According to this: https://bugs.gentoo.org/show_bug.cgi?id=538920 The problem is that M2Crypto is using SWIG 3.0.5. My Tumbleweed used 3.0.4 instead, but 12 days ago 3.0.5 landed in Factory (still unpublished). If I am not wrong, this means that http://download.opensuse.org/repositories/devel:/languages:/python/openSUSE_Tumbleweed/ is using 3.0.5 here. The easy workaround can be install the version form http://download.opensuse.org/tumbleweed/repo/oss/suse/x86_64/python-M2Crypto-0.22.3-3.2.x86_64.rpm I will check what is the problem with swig