Comment # 4 on bug 1205162 from Petr Gajdos

(In reply to Eric Schirra from comment #3)
> No, that is not enough.
> I had to add the following to /etc/php7/apache2/php.ini:
> Extension=mysqlnd.
> Only then did the applications work again.

To repeat comment 2:

(In reply to Petr Gajdos from comment #2)
> However, I am trying to understand how your problem is caused. On a 15.4

The very same line (extension=mysqlnd) is present already in
/etc/php7/conf.d/_mysqlnd.ini and in case I add it into
/etc/php7/apache2/php.ini I could not get anything else than:

PHP Warning:  Module 'mysqlnd' already loaded in Unknown on line 0
[Wed Jan 04 12:22:30.402842 2023] [mpm_prefork:notice] [pid 7666] AH00163:
Apache/2.4.51 (Linux/SUSE) OpenSSL/1.1.1l PHP/7.4.33 configured -- resuming
normal operations

in error_log. So, could you please try to figure out why _mysqlnd.ini is not
taken into account on your system? Could you try to inspect phpinfo() run
trough apache sapi? Perhaps also php -m output (warnings/errors)?