Comment # 4 on bug 1206760 from Friedemann Schmieg

Created attachment 863765 [details]
alsa-info after install pipewire-pulseaudio and reboot

Done as recommended. Package installed and rebooted. New ALSA Info attached.
Have now 2 different processes as expected:

itsme  8900  3209  1 10:20 ?        00:00:29 /usr/bin/pipewire
itsme  8902  3209  0 10:20 ?        00:00:19 /usr/bin/pipewire-pulse

But result is the same:

/usr/bin/aplay --device plughw:CARD=CMI8738 /home/itsme/Sounds/test.wav
aplay: main:831: audio open error: Device or resource busy

or

sudo -u itsme /usr/bin/aplay --device plughw:CARD=CMI8738
/home/itsme/Sounds/test.wav
aplay: main:831: audio open error: Device or resource busy