I spent some more time troubleshooting this issue. This is what I found out. I installed steam and ran a few native games, no system freezes that I could replicate. I want to point out that before the bug was closed in April 2018 even native games were freezing the system. The system freeze issue seem to happen only when running games via Wine since I reopened the bug. I went further on that and asked some friends that use macOS and run the same game, and I was very surprised to hear they are having the same issue. So I went ahead and involved codeweavers on this. I shared this bug and the one I opened upstream. They are investigating and they said they can also replicate this system freeze. I will update the bug tracker as I get more information.