I'm guessing that the scanner was somehow put in an odd state, perhaps because it's been used from the working desktop over the weekend, so I did the following powered the scanner off/on scanimage --mode color --resolution 300 >office12-300dpi-2.pnm (scan worked, colours distorted) scanimage --mode color --resolution 150 >office12-image150-3.pnm (scan worked, colours are fine) strace etc. scanimage --mode color --resolution 300 >office12-300dpi-3.pnm (scan worked, colours distorted) I can attach the last strace if you want.