I ran virt-manager using the suggested su - from a terminal. After connecting, I launched my virtual machine and the usual shutdown occurred. However I found the following in the terminal: libsoup-ERROR **: 14:13:06.377: libsoup3 symbols detected. Using libsoup2 and libsoup3 in the same process is not supported. I tried to uninstall libsoup3 directly, but ran into a bunch of problems that needed to be solved, primarily with yelp. So I uninstalled yelp, which allowed me to uninstall libsoup3, which allowed me to run my VM using virt-manager, both as root and then as user. I have marked libsoup3 as taboo and was able to execute a zypper dup without issue. I am not sure what has caused this situation, but it appears to have fixed my problem.